Dynamic changes in the transcriptome and metabolome of pig ovaries across developmental stages and gestation.

ABSTRACT:

Background

The ovary is a central organ in the reproductive system that produces oocytes and synthesizes and secretes steroid hormones. Healthy development and regular cyclical change in the ovary is crucial for regulating reproductive processes. However, the key genes and metabolites that regulate ovarian development and pregnancy have not been fully elucidated. This study conducted high-throughput RNA sequencing and untargeted metabolite profiling of the ovarian tissues from Chenghua pigs at four stages, including postnatal day 3 (D3), puberty at the age of about 125 days (Pub), sexual maturity at the age of about 365 days (Y1), and 105 days after pregnancy at the age of about 360 days (Pre).

Results

A total of 9,264 and 1,593 differentially expressed genes (DEGs) were ide

SUBMITTER: Pan B 

PROVIDER: S-EPMC11654078 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature