Prognostic, oncogenic roles, and pharmacogenomic features of AMD1 in hepatocellular carcinoma.

ABSTRACT:

Background

AMD1 is the gene encoding S-adenosylmethionine decarboxylase 1. How AMD1 affects the prognosis of hepatocellular carcinoma (HCC) patients is unclear.

Methods

Using the Cancer Genome Atlas (TCGA) liver hepatocellular carcinoma datasets, gene enrichment and immunological traits were compared between groups with high and low AMD1 expression. After altering AMD1 expression in HCC cells, cell viability, the clonal formation rate, and migration and invasion ability were detected. Univariate Cox regression analysis and Pearson correlation were used to screen for AMD1-related genes (ARGs). Multidimensional bioinformatic algorithms were utilized to establish a risk score model for ARGs.

Results

AMD1 expression was notably increased in the majority of cancer types. H

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11654270 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature