Genome-wide association studies unveil major genetic loci driving insecticide resistance in Anopheles funestus in four eco-geographical settings across Cameroon.

ABSTRACT:

Background

Insecticide resistance is jeopardising malaria control efforts in Africa. Deciphering the evolutionary dynamics of mosquito populations country-wide is essential for designing effective and sustainable national and subnational tailored strategies to accelerate malaria elimination efforts. Here, we employed genome-wide association studies through pooled template sequencing to compare four eco-geographically different populations of the major vector, Anopheles funestus, across a South North transect in Cameroon, aiming to identify genomic signatures of adaptive responses to insecticides.

Results

Our analysis revealed limited population structure within Northern and Central regions (F_ST<0.02), suggesting extensive gene flow, while populations from the Litt

SUBMITTER: Gadji M 

PROVIDER: S-EPMC11654272 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature