A qualitative study exploring stakeholders' perceptions of registry-based randomised controlled trials capacity and capability in Australia.

ABSTRACT:

Background

Traditional randomised controlled trials (RCTs) are the gold standard for evaluating the effectiveness of interventions in clinical research. Traditional RCTs however are complex, expensive and have low external validity. Registry-based randomised controlled trials (RRCTs) are an emerging alternative approach that integrates the internal validity of a traditional RCT with the external validity of a clinical registry by recruiting more real-world patients and leveraging an existing registry platform for data collection. As RRCTs are a novel research design, there is limited understanding of the RRCT landscape in Australia. This qualitative study aims to explore the RRCT landscape in Australia including current capacity and capabilities, and to identify challenges and oppo

SUBMITTER: Karanatsios B 

PROVIDER: S-EPMC11654275 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature