Association of serum Klotho with the severity and mortality among adults with cardiovascular-kidney-metabolic syndrome.

ABSTRACT:

Background

Cardiovascular-kidney-metabolic (CKM) syndrome is characterized as a systemic disease resulting from the pathophysiological interplay among metabolic risk factors, chronic kidney disease (CKD), and cardiovascular disease (CVD). The Klotho protein may serve as a novel biomarker. However, the utility of serum Klotho levels as an indicator of severity and mortality risk in CKM syndrome remains uncertain.

Methods

This study involved 9,871 participants from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2016. Serum Klotho levels were measured using an enzyme-linked immunosorbent assay kit. The optimal cutoff value was established through the maximum Youden's index. Multivariable weighted regression models were employed to calcu

SUBMITTER: Tang J 

PROVIDER: S-EPMC11654297 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature