A case report about focal status epilepticus as first presentation in Alzheimer's disease: finding the culprit.

ABSTRACT:

Background

Neuronal hyperexcitability has been proposed to play a key role in Alzheimer's disease (AD). Understanding the relation between this enhanced excitability and AD pathology could provide a window for therapeutic interventions. However epileptiform activity is often subclinical, hidden on scalp EEG and very challenging to assess with current diagnostic modalities.

Case presentation

A woman in her sixties presented with acute confusion. Despite a normal scalp electroencephalogram (EEG), magnetic resonance imaging (MRI) showed cytotoxic edema of the right mesial temporal lobe and hippocampal hypermetabolism was present on ([¹⁸F]-fluoro-2-deoxyglucose positron emission tomography (PET). Bilateral foramen ovale (FO) electrodes were placed to directly record m

SUBMITTER: Devulder A 

PROVIDER: S-EPMC11654376 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature