Fracture incidence in women: the impact of reproductive characteristics.

ABSTRACT:

Background

Although endogenous estrogen exposure, influenced by reproductive factors (RFs), is negatively associated with fracture risk, there is limited and conflicting information on the association between these factors and the incidence of fractures. This study aimed to evaluate the association between RFs and fracture incidence (FXI) separately.

Methods

This longitudinal study commenced in 1999 and concluded in 2021. It is performed on women without previous fractures and adjusted for confounders. RFs, including age at menarche, parity, abortion, duration of breastfeeding (BF), hormonal contraceptive use, and age at menopause, were exposure variables. The incidence of fractures was the primary outcome. A Cox proportional hazards regression model was used to estimate the

SUBMITTER: Farahmand M 

PROVIDER: S-EPMC11654412 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature