Exploring the relationship between gut microbiota and breast diseases using Mendelian randomization analysis.

ABSTRACT:

Background

Growing evidence suggests a relationship between gut microbiota composition and breast diseases, although the precise nature of this association remains uncertain. To investigate the causal relationship between gut microbiota and breast diseases, we utilized two-way Mendelian randomization (MR) analysis.

Methods

Four common diseases were included as outcomes: breast cancer, breast cysts, inflammatory disorders of the breast, and infections of the breast associated with childbirth, along with their subtypes. Genetic data on gut microbiota were extracted from genome-wide association studies (GWAS). The primary approach used to investigate the association between these genetic factors and gut microbiota was the inverse-variance-weighted (IVW) method with random-effec

SUBMITTER: Wang X 

PROVIDER: S-EPMC11654425 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature