Increased TRPV4 Channel Expression Enhances and Impairs Blood Vessel Function in Hypertension.

ABSTRACT:

Background

Endothelial cell TRPV4 (transient receptor potential vanilloid 4) channels provide a control point that is pivotal in regulating blood vessel diameter by mediating the Ca²⁺-dependent release of endothelial-derived vasoactive factors. In hypertension, TRPV4-mediated control of vascular function is disrupted, but the underlying mechanisms and precise physiological consequences remain controversial.

Methods

Here, using a comprehensive array of methodologies, endothelial TRPV4 channel function was examined in intact mesenteric resistance arteries from normotensive Wistar-Kyoto and spontaneously hypertensive rats.

Results

Our results show there is a notable shift in vascular reactivity in hypertension characterized by enhanced endothelium-dependent va

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11654454 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature