Hydroalkylation of unactivated olefins with C(sp³)─H compounds enabled by NiH-catalyzed radical relay.

ABSTRACT: The hydroalkylation reaction of olefins with alkanes is a highly desirable synthetic transformation toward the construction of C(sp³)─C(sp³) bonds. However, such transformation has proven to be challenging for unactivated olefins, particularly when the substrates lack directing groups or acidic C(sp³)─H bonds. Here, we address this challenge by merging NiH-catalyzed radical relay strategy with a HAT (hydrogen atom transfer) process. In this catalytic system, a nucleophilic alkyl radical is generated from a C(sp³)─H compound in the presence of a HAT promotor, which couples with an alkyl metallic intermediate generated from the olefin substrate with a NiH catalyst to form the C(sp³)─C(sp³) bond. Starting from easily available

SUBMITTER: Shi JL 

PROVIDER: S-EPMC11654677 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature