N-glycan as new potential biomarker for predicting treatment response in patients with type 2 diabetes mellitus.

ABSTRACT:

Aims

To investigate the N-glycans related to the metformin efficacy in patients with type 2 diabetes mellitus (T2DM).

Materials and methods

We enrolled 141 healthy controls and 195 newly diagnosed T2DM patients treated with metformin for 3 months. Serum N-glycan profile was determined by DNA sequencer - assisted fluorophore-assisted carbohydrate electrophoresis (DSA-FACE). The N-glycan model was established by logistic regression analysis. Receiver operating characteristic curve (ROC) analysis was used to analyze the predictive power of the N-glycan model for metformin efficacy.

Results

The abundances of several N-glycans in serum of T2DM patients at baseline were significantly different from those of healthy controls and tended to recover the N-glycan of controls aft

SUBMITTER: Dong HJ 

PROVIDER: S-EPMC11654830 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature