Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains.

ABSTRACT: A key aspect of nutrient absorption is the exquisite division of labour across the length of the small intestine, with individual nutrients taken up at different proximal:distal positions. For millennia, the small intestine was thought to comprise three segments with indefinite borders: the duodenum, jejunum and ileum. By examining the fine-scale longitudinal transcriptional patterns that span the mouse and human small intestine, we instead identified five domains of nutrient absorption that mount distinct responses to dietary changes, and three regional stem cell populations. Molecular domain identity can be detected with machine learning, which provides a systematic method to computationally identify intestinal domains in mice. We generated a predictive model of transcriptional control o

SUBMITTER: Zwick RK 

PROVIDER: S-EPMC11654995 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature