IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Rodent reproductive behavior among males and females after exposure to endocrine-disrupting chemicals.

ABSTRACT:

In brief

The rodent reproductive behavioral control column of the hypothalamus and the hypothalamic-pituitary-gonadal (HPG) axis are critical systems that regulate copulatory behaviors in both males and females. We review how endocrine-disrupting chemicals (EDCs), specifically phthalates, bisphenol A, and chemical mixtures, dysregulate appetitive and consummatory copulatory behaviors and their neuroendocrine substrates, using mouse and rodent models.

Abstract

Sexual reproduction - from both physiological and behavioral perspectives - is dependent upon appropriate connections between a diverse, hormone-modulated network of neural regions. Importantly, these substrates are regulated by hormones across the lifespan from early development to adulthood, making them targets of EDC

SUBMITTER: Maxon JR 

PROVIDER: S-EPMC11655000 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature