Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens.

ABSTRACT: The global rise of antibiotic resistance calls for new drugs against bacterial pathogens. A common approach is to search for natural compounds deployed by microbes to inhibit competitors. Here, we show that the iron-chelating pyoverdines, siderophores produced by environmental Pseudomonas spp., have strong antibacterial properties by inducing iron starvation and growth arrest in pathogens. A screen of 320 natural Pseudomonas isolates used against 12 human pathogens uncovered several pyoverdines with particularly high antibacterial properties and distinct chemical characteristics. The most potent pyoverdine effectively reduced growth of the pathogens Acinetobacter baumannii, Klebsiella pneumoniae, and Staphylococcus aureus in a concentration- and iron-depe

SUBMITTER: Vollenweider V 

PROVIDER: S-EPMC11655065 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature