Irisin Alleviates Cognitive Impairment by Inhibiting AhR/NF-<i>κ</i>B-NLRP3-Mediated Pyroptosis of Hippocampal Neurons in Chronic Kidney Disease.

ABSTRACT: Introduction: Cognitive impairment is a vital complication of chronic kidney disease (CKD). The effect of irisin on CKD-induced cognitive impairment remains unclear. In the present study, we aimed to investigate the role of Irisin in mitigating cognitive impairment and explore the underlying mechanisms in CKD. Methods: A CKD mice model was established by adenine. Cognitive function was assessed via the novel object recognition (NOR). Interleukin-1β (IL-1β) levels were measured by enzyme-linked immunosorbent assay (ELISA), while pyroptosis-related protein expression was analyzed using western blotting. Results: Our data showed an upregulation of cell pyroptosis in hippocampus tissues of CKD mice, accompanied by significant cognitive impairment. Pyroptosis

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11655147 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature