Identifying sex similarities and differences in structure and function of the sinoatrial node in the mouse heart.

ABSTRACT:

Background

The sinoatrial node (SN) generates the heart rate (HR). Its spontaneous activity is regulated by a complex interplay between the modulation by the autonomic nervous system (ANS) and intrinsic factors including ion channels in SN cells. However, the systemic and intrinsic regulatory mechanisms are still poorly understood. This study aimed to elucidate the sex-specific differences in heart morphology and SN function, particularly focusing on basal HR, expression and function of hyperpolarization-activated HCN4 and HCN1 channels and mRNA abundance of ion channels and mRNA abundance of ion channels contributing to diastolic depolarization (DD) and spontaneous action potentials (APs).

Methods

Body weight, heart weight and tibia length of 2- to 3-month-old male and fema

SUBMITTER: Yin Z 

PROVIDER: S-EPMC11655232 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature