HiCrayon reveals distinct layers of multi-state 3D chromatin organization.

ABSTRACT: Chromatin contact maps are often shown as 2D heatmaps and visually compared to 1D genomic data by simple juxtaposition. While common, this strategy is imprecise, placing the onus on the reader to align features with each other. To remedy this, we developed HiCrayon, an interactive tool that facilitates the integration of 3D chromatin organization maps and 1D datasets. This visualization method integrates data from genomic assays directly into the chromatin contact map by coloring interactions according to 1D signal. HiCrayon is implemented using R shiny and python to create a graphical user interface application, available in both web and containerized format to promote accessibility. We demonstrate the utility of HiCrayon in visualizing the effectiveness of compartment calling and the rel

SUBMITTER: Nolan B 

PROVIDER: S-EPMC11655295 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature