ReAlign-N: an integrated realignment approach for multiple nucleic acid sequence alignment, combining global and local realignments.

ABSTRACT: Ensuring accurate multiple sequence alignment (MSA) is essential for comprehensive biological sequence analysis. However, the complexity of evolutionary relationships often results in variations that generic alignment tools may not adequately address. Realignment is crucial to remedy this issue. Currently, there is a lack of realignment methods tailored for nucleic acid sequences, particularly for lengthy sequences. Thus, there's an urgent need for the development of realignment methods better suited to address these challenges. This study presents ReAlign-N, a realignment method explicitly designed for multiple nucleic acid sequence alignment. ReAlign-N integrates both global and local realignment strategies for improved accuracy. In the global realignment phase, ReAlign-N incorporates K-

SUBMITTER: Zhai Y 

PROVIDER: S-EPMC11655299 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature