Thymic stromal lymphopoietin modulates T cell response and improves cardiac repair post-myocardial infarction.

ABSTRACT:

Background

The inflammatory response is associated with cardiac repair and ventricular remodeling after myocardial infarction (MI). The key inflammation regulatory factor thymic stromal lymphopoietin (TSLP) plays a critical role in various diseases. However, its role in cardiac repair after MI remains uncertain. In this study, we elucidated the biological function and mechanism of action of TSLP in cardiac repair and ventricular remodeling following MI.

Method and result

Wild-type and TSLP receptor (TSLPR)-knockout (Crlf2^-/-) mice underwent MI induction via ligation of the left anterior descending artery. TSLP expression was upregulated in the infarcted heart, with a peak observed on day 7 post-MI. TSLP expression was enriched in the cardiomyocytes of infar

SUBMITTER: Wang X 

PROVIDER: S-EPMC11655303 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature