Association between herpes zoster and Parkinson's disease and dementia: a systematic review and meta-analysis.

ABSTRACT:

Objectives

This meta-analysis investigated the relationship between herpes zoster and the risk of dementia or Parkinson's disease by analyzing published clinical studies.

Methods

We systematically searched PubMed, Cochrane, Embase, and Web of Science Core Collection databases on April 25, 2024. Hazard ratios (HR) were used for statistical analyses. Random-effects models were applied, and heterogeneity was assessed using the I² statistic.

Results

Herpes zoster was associated with a non-significant trend toward increased dementia risk (HR = 1.11, 95% CI 0.99-1.24, p = 0.07) but significantly increased Parkinson's disease risk (HR = 1.15, 95% CI 1.03-1.30, p = 0.02). Subgroup analyses revealed that herpes zoster significantly elevated the risk of

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11655326 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature