Developing a universal multi-epitope protein vaccine candidate for enhanced borna virus pandemic preparedness.

ABSTRACT:

Introduction

Borna disease virus 1 (BoDV-1) is an emerging zoonotic RNA virus that can cause severe acute encephalitis with high mortality. Currently, there are no effective countermeasures, and the potential risk of a future outbreak requires urgent attention. To address this challenge, the complete genome sequence of BoDV-1 was utilized, and immunoinformatics was applied to identify antigenic peptides suitable for vaccine development.

Methods

Immunoinformatics and antigenicity-focused protein screening were employed to predict B-cell linear epitopes, B-cell conformational epitopes, and cytotoxic T lymphocyte (CTL) epitopes. Only overlapping epitopes with antigenicity greater than 1 and non-toxic, non-allergenic properties were selected for subsequent vaccine construction.

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11655343 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature