Comprehensive analysis of skin growth-related hub genes and microenvironment characterization in a mouse expanded skin model.

ABSTRACT:

Background

Mechanical stretch-mediated tissue expansion is effective for obtaining extra skin and soft tissue required for the repair of defects or reconstruction of surface organs. Understanding the cellular and molecular mechanisms and identifying hub genes and key cell types associated with skin expansion could help predict the success of skin growth during expansion procedures.

Methods

We analyzed murine chip sequencing data and single-cell sequencing data available from the Gene Expression Omnibus database. Based on the differentially expressed and epithelial-mesenchymal transition-related genes, random forest and protein-protein interaction network analysis identified hub genes for predicting skin regeneration in tissue expansion. The fate of the cell subpopulations, e

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11655345 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature