Study design features increase replicability in brain-wide association studies.

ABSTRACT: Brain-wide association studies (BWAS) are a fundamental tool in discovering brain-behaviour associations^1,2. Several recent studies have shown that thousands of study participants are required for good replicability of BWAS^1-3. Here we performed analyses and meta-analyses of a robust effect size index using 63 longitudinal and cross-sectional MRI studies from the Lifespan Brain Chart Consortium⁴ (77,695 total scans) to demonstrate that optimizing study design is critical for increasing standardized effect sizes and replicability in BWAS. A meta-analysis of brain volume associations with age indicates that BWAS with larger variability of the covariate and longitudinal studies have larger reported standardized effect size. Analysing age effects on global and

SUBMITTER: Kang K 

PROVIDER: S-EPMC11655360 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature