Predictive value of serum neurofilament light chain for cognitive impairment in Parkinson's disease.

ABSTRACT:

Background

Neurofilament light chain (NfL) has recently emerged as a key indicator of neurodegeneration. In this study, our hypothesis is that the levels of blood-derived NfL and its accumulation during the Parkinson's disease (PD) progression could serve as a potential biomarker for predicting subsequent cognitive decline. To investigate this, we conducted a study utilizing a large single-center cohort.

Methods

The study included 193 participants, consisting of 106 cognitively normal PD (PD-CN) patients and 87 normal controls (NC) individuals. Serum NfL concentrations were measured. PD patients were followed up for clinical assessment at an average of 2 ± 0.6 years.

Results

The serum NfL levels were significantly higher in PD-CN patients compared to NC. PD-CN patient

SUBMITTER: Gu L 

PROVIDER: S-EPMC11655485 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature