BIRC5 as a prognostic and diagnostic biomarker in pan-cancer: an integrated analysis of expression, immune subtypes, and functional networks.

ABSTRACT:

Introduction

BIRC5 (Survivin) is a crucial anti-apoptotic protein overexpressed in various cancers, promoting tumor growth and treatment resistance. This study investigates its expression across 33 cancer types and explores its diagnostic, prognostic, and immune-related significance.

Methods

We analyzed RNA-seq data from TCGA and protein expression data from the Human Protein Atlas. Expression levels were compared between tumor and normal tissues. Correlations with molecular and immune subtypes were explored using TISIDB. Prognostic significance was evaluated through survival analysis, Cox regression, and ROC curve analysis. The PPI network was constructed using STRING.

Results

BIRC5 was significantly overexpressed in tumor tissues across 33 cancer types, with higher

SUBMITTER: Li G 

PROVIDER: S-EPMC11655497 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature