Nernst-Planck-Gaussian finite element modelling of Ca²⁺ electrodiffusion in amphibian striated muscle transverse tubule-sarcoplasmic reticular triadic junctional domains.

ABSTRACT:

Introduction

Intracellular Ca²⁺ signalling regulates membrane permeabilities, enzyme activity, and gene transcription amongst other functions. Large transmembrane Ca²⁺ electrochemical gradients and low diffusibility between cell compartments potentially generate short-lived, localised, high-[Ca²⁺] microdomains. The highest concentration domains likely form between closely apposed membranes, as at amphibian skeletal muscle transverse tubule-sarcoplasmic reticular (T-SR, triad) junctions.

Materials and methods

Finite element computational analysis characterised the formation and steady state and kinetic properties of the Ca²⁺ microdomains using established empirical physiological and anatomical values. It progressively incorporated F

SUBMITTER: Rodriguez MD 

PROVIDER: S-EPMC11655509 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature