Prefrontal cortex stimulation normalizes deficient adaptive learning from outcome contingencies in low mood.

ABSTRACT: Depression and anxiety are associated with deficits in adjusting learning behaviour to changing outcome contingencies. This is likely to drive and maintain symptoms, for instance, by perpetuating negative biases or a sense of uncontrollability. Normalising such deficits in adaptive learning might therefore be a novel treatment target for affective disorders. The aim of this experimental medicine study was to test whether prefrontal cortex transcranial direct current stimulation (tDCS) could normalise these aberrant learning processes in depressed mood. To test proof-of-concept, we combined tDCS with a decision-making paradigm that manipulates the volatility of reward and punishment associations. 85 participants with low mood received tDCS during (or before) the task. In two sessions partic

SUBMITTER: Sarrazin V 

PROVIDER: S-EPMC11655553 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature