NCF-1 plays a pivotal role in the survival of adenocarcinoma cells of pancreatic and gastric origins.

ABSTRACT: Reactive oxygen species (ROS) play a pivotal biological role in cells, with ROS function differing depending on cellular conditions and the extracellular environment. Notably, ROS act as cytotoxic factors to eliminate infectious pathogens or promote cell death under cellular stress, while also facilitating cell growth (via ROS-sensing pathways) by modifying gene expression. Among ROS-related genes, neutrophil cytosolic factor-1 (NCF-1; p47phox) was identified as a ROS generator in neutrophils. This product is a subunit of a cytosolic NADPH oxidase complex activated in response to pathogens such as bacteria and viruses. NCF-1 has been examined primarily in terms of ROS-production pathways in macrophages and neutrophils; however, the expression of this protein and its biological role in canc

SUBMITTER: Furuya-Ikude C 

PROVIDER: S-EPMC11655584 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature