Radiotherapy and inflammaging: the influence of prostate cancer radiotherapy on systemic inflammation.

ABSTRACT:

Purpose

The present study was performed to investigate the association of prostate cancer radiotherapy with inflammaging, a condition characterized by the elevation of inflammatory blood parameters that significantly increases the susceptibility to the occurrence or progression of age-related conditions.

Patients and methods

A total of 306 patients treated with curative radiotherapy (RT) for prostate cancer were enrolled into the prospective study. Aging-related inflammatory parameters including C-reactive protein (CRP), albumin, fibrinogen, cholesterol, platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were analyzed before and at the end of RT, and 3 and 15 months after completion of the RT. Statistical analysis was performed using non-parametric

SUBMITTER: Paal K 

PROVIDER: S-EPMC11655599 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature