S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway.

ABSTRACT: Compiling evidence has indicated that S100A11 expression at high levels is closely associated with various cancer species. Consistent with the results reported elsewhere, we have also revealed that S100A11 is highly expressed in squamous cell carcinoma, mesothelioma, and pancreatic cancers and plays a crucial role in cancer progression when secreted into extracellular fluid. Those studies are all focused on the extracellular role of S100A11. However, most of S100A11 is still present within cancer cells, although the intracellular role of S100A11 in cancer cells has not been fully elucidated. Thus, we aimed to investigate S100A11 functions within cancer cells, primarily focusing on colorectal cancer cells, whose S100A11 is abundantly present in cells and still poorly studied cancer for the

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11655616 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature