Optimizing accrual to a large-scale, clinically integrated randomized trial in anesthesiology: A 2-year analysis of recruitment.

ABSTRACT:

Background

Performing large randomized trials in anesthesiology is often challenging and costly. The clinically integrated randomized trial is characterized by simplified logistics embedded into routine clinical practice, enabling ease and efficiency of recruitment, offering an opportunity for clinicians to conduct large, high-quality randomized trials under low cost. Our aims were to (1) demonstrate the feasibility of the clinically integrated trial design in a high-volume anesthesiology practice and (2) assess whether trial quality improvement interventions led to more balanced accrual among study arms and improved trial compliance over time.

Methods

This is an interim analysis of recruitment to a cluster-randomized trial investigating three nerve block approaches for mast

SUBMITTER: Tokita HK 

PROVIDER: S-EPMC11655704 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature