Unraveling the causal relationship between serum minerals and pancreatic cancer: a Mendelian randomization study.

ABSTRACT:

Background

Pancreatic cancer is among the most lethal malignancies, characterized by a poor prognosis and limited modifiable factors. Emerging evidence indicates that serum mineral levels may influence the likelihood of developing pancreatic cancer. However, the causal relationship between serum minerals and pancreatic cancer remains unclear and warrants further investigation.

Methods

This Mendelian randomization (MR) study was conducted to explore the causal effects of serum mineral levels on pancreatic cancer risk. Genetic variants associated with serum mineral levels, including calcium, iron, magnesium, zinc, selenium, and copper, were selected as instrumental variables (IVs) from large-scale genome-wide association study (GWAS) data. Multiple methods, including inverse v

SUBMITTER: Liu C 

PROVIDER: S-EPMC11655719 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature