Role of lncRNA TPRG1-AS1 in the development of cervical squamous cell carcinoma and its prognostic value.

ABSTRACT:

Objective

Cervical squamous cell carcinoma (CSCC) has a poor prognosis due to persistent HPV infection. LncRNA TPRG1-AS1 is linked to regulating the development of many cancers, so the regulatory mechanism and prognostic value of TPRG1-AS1 in CSCC were explored.

Methods

138 patients with cervical cancer were included. TPRG1-AS1 expression and miR-590-3p were analyzed by qRT-PCR. The association between TPRG1-AS1 and clinicopathological features was investigated. Independent prognostic factors of CSCC were analyzed by multifactorial Cox regression. Patient survival was analyzed using Kaplan-Meier plotter curves. CCK-8 was employed to evaluate the proliferative capacity of the cells. Transwell assays were performed to evaluate the effects of TPRG1-AS1 and miR-590-3p on cell mi

SUBMITTER: Fan Y 

PROVIDER: S-EPMC11655740 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature