Production of high purity ⁴⁷Sc from proton irradiation of natural vanadium targets.

ABSTRACT:

Background

Scandium-47 is the therapeutic counterpart to the diagnostic radionuclides, ⁴³Sc and ⁴⁴Sc. Together, these form elementally matched theranostic nuclide pairs, but their incorporation into radiopharmaceuticals requires developing production techniques leading to radioscandium isotopes with high chemical and radionuclidic purity. Previous ⁴⁷Sc production methods involved expensive, enriched titanium targets that require additional procedures for target recovery. This work investigates the irradiation of natural vanadium targets and the development of purification methods for high-purity ⁴⁷Sc. Natural vanadium foils were used in cyclotron target configurations. Targets were irradiated with 24 MeV protons at currents of up to 80 µA

SUBMITTER: Cingoranelli SJ 

PROVIDER: S-EPMC11655753 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature