Addressing lung truncation in ^99mTc-MAA SPECT/CT for ⁹⁰Y microsphere radioembolization treatment planning.

ABSTRACT:

Background

Prior studies have established that macroaggregated albumin (MAA)-SPECT/CT offers more robust lung shunt fraction (LSF) and lung mean absorbed dose (LMD) estimates in ⁹⁰Y radioembolization in comparison to planar imaging. However, incomplete SPECT/CT coverage of the lungs is common due to clinical workflows, complicating its potential use for LSF and LMD calculations. In this work, lung truncation in MAA-SPECT/CT was addressed via correction strategies to improve ⁹⁰Y treatment planning.

Methods

Lung truncation was simulated in 56 cases with adequate (> 90%, mean: 98%) lung coverage in MAA-SPECT/CT by removing slices in ~ 5 mm increments from the lung apices to the diaphragm. A wide range of lung coverages from 100% to < 1% in ~ 2% increments

SUBMITTER: Thomas MA 

PROVIDER: S-EPMC11655778 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature