MicroRNA-875-5p-conjugated gold nanoparticles suppress breast cancer progression through the MTDH/PTEN/AKT signaling pathway.

ABSTRACT:

Objective

A lack of effective delivery methods has hampered the study of therapeutics targeting miR-875-5p for breast cancer (BC).

Methods

The miR-875-5p mimic was conjugated to AuNPs to produce AuNP-miR-875-5p. Then, the effect of AuNP-miR-875-5p on the proliferative, migratory, invasive activities, and apoptosis of BC cells was detected, as well as on tumor growth in animals. The involvement of the MTDH/PTEN/AKT pathway in miR-875-5p-mediated BC progression was identified.

Results

AuNP-miR-875-5p was delivered to BC cells and hampered cell malignancy. MTDH was targeted by miR-875-5p. MTDH expression was negatively correlated with miR-875-5p expression in BC tissues. The anti-tumor effect of AuNP-miR-875-5p in BC cells was counteracted by MTDH overexpression. AuNP-mi

SUBMITTER: Xiong B 

PROVIDER: S-EPMC11655799 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature