Production of [¹⁸F]DPA-714, [¹⁸F]fallypride and [¹⁸F]LBT-999 using iMiDEV, a fully automated microfluidic platform: towards clinical radiopharmaceutical production.

ABSTRACT:

Background

Positron emission tomography is widely used to study biological processes without disrupting normal physiological functions. Traditional radiotracer synthesis and industrial market is focused on producing large batches of ¹⁸F-labelled tracers, especially [¹⁸F]FDG. Accessibility to smaller quantity of diverse radiopharmaceuticals is a key to enable a more personalised approach in nuclear medicine. A novel microfluidic module, iMiDEV™, has earlier been shown to be a versatile labelling platform as it has been used in the production of Na[¹⁸F]F and various ¹¹C- and ⁶⁸ Ga-labelled tracers. In the current study our aim was to utilise iMiDEV™ in the synthesis of fluorine-18-labelled radiotracers, specifically [¹⁸

SUBMITTER: Lahdenpohja S 

PROVIDER: S-EPMC11655818 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature