Systematic review and meta-analysis of COVID-19 mRNA vaccine effectiveness against hospitalizations in adults.

ABSTRACT:

Background

During the coronavirus disease 2019 (COVID-19) pandemic, Pfizer/BioNTech BNT162b2, and Moderna mRNA-1273 vaccines were central to the global pandemic control measures.

Methods

Here, we conducted a systematic review and meta-analysis to evaluate their real-world vaccine effectiveness (VE). Our study focussed on those that reported the efficacy of these vaccines against COVID-19 hospitalization. Hospitalization was chosen as the primary outcome as it directly reflects the ability of the vaccine to prevent severe disease. A literature search was undertaken using Medline and Embase on 25 February 2024. From this, 50 studies out of 18,347 articles were included for further analysis.

Results

High VE against hospitalization was reported for both the BNT162b2 and m

SUBMITTER: Wong BK 

PROVIDER: S-EPMC11655844 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature