Longitudinal Changes in Peak Expiratory Flow Predict Risk for Incident Dementia.

ABSTRACT:

Background

Impaired respiratory function, measured via peak expiratory flow (PEF), has been associated with increased dementia risk. However, much of the current literature uses cross-sectional measures of PEF, whereas longitudinal relationships between changes in respiratory function and dementia risk are underexplored.

Methods

Using 10 years of data (2011-2021) from 2 439 adults ages 65 and older in the National Health and Aging Trends Study, we examined whether 5-year changes in PEF (2011-2016) were associated with risk for incident dementia over the subsequent 5-year period (2017-2021). PEF slopes for each participant were estimated using linear mixed-effects models and then grouped into quartiles: rapid, moderate, mild, and no declines. Discrete-time Cox proportional ha

SUBMITTER: Donahue PT 

PROVIDER: S-EPMC11655845 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature