Rapid and scalable ruthenium catalyzed meta-C-H alkylation enabled by resonant acoustic mixing.

ABSTRACT: Synthetic chemistry approaches for direct C-H bond alkylation offers a promising alternative to traditional functional-group-centered strategies which often involve multi-step procedures and may suffer from a variety of challenges including scalability. Here, we introduce resonant mixing as an efficient method for meta-C-H alkylation of arenes using a Ru-catalyst, avoiding the need for bulk solvents, external temperature, or light. The described methodology is highly rapid, enabling multigram-scale synthesis of meta-alkylation products within a short reaction time and achieving a very high turnover frequency. The reaction operates via a radical mechanism and is characterized by its mild reaction conditions, substrate compatibility, and exceptional meta-selectivity, all while significantly

SUBMITTER: Dey A 

PROVIDER: S-EPMC11655853 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature