Alterations of the endocannabinoid system in adolescents with non-suicidal self-injury as a function of childhood maltreatment.

ABSTRACT: Non-suicidal self-injury (NSSI) is a highly prevalent phenomenon in adolescence, often associated with prior traumatic experiences. The development and maintenance of NSSI is associated with dysregulation of the stress response, and evidence suggests that the hypothalamic-pituitary-adrenal (HPA) axis plays an important role. The endocannabinoid system is a neuromodulatory system in close functional interaction with the HPA axis. Several studies have reported alterations of the endocannabinoid system in adult patients with post-traumatic stress disorder. However, the role of the endocannabinoid system in children and adolescents with NSSI is less clear, and previously no study examined endocannabinoids in youth with experiences of maltreatment. N-arachidonyl ethanolamide (AEA) and 2-arachid

SUBMITTER: Ferger MD 

PROVIDER: S-EPMC11655887 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature