Identification of a pyroptosis-related prognostic model for colorectal cancer and validation of the core gene SPTBN5.

ABSTRACT:

Background

Pyroptosis, an emerging type of programmed cell death. The mechanisms of pyroptosis mainly include inflammasome-activated pyroptosis and non-inflammasome-activated pyroptosis. Multiple prognostic scoring systems that utilize pyroptosis-related gene expression have been validated as effective predictors of patient outcomes. But the relationship between pyroptosis and colorectal cancer remains unclear. This study has established a gene signature associated with pyroptosis to forecast the prognosis of CRC patients.

Methods

An analysis of 52 pyroptosis genes was conducted in both CRC and normal colorectal tissues, leading to the discovery of differentially expressed genes (DEGs). Core pyroptosis-related genes were identified using least absolute shrinkage and selectio

SUBMITTER: Li G 

PROVIDER: S-EPMC11656000 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature