GWASBrewer: An R Package for Simulating Realistic GWAS Summary Statistics.

ABSTRACT: Many statistical genetics analysis methods make use of GWAS summary statistics. Best statistical practice requires evaluating these methods in realistic simulation experiments. However, simulating summary statistics by first simulating individual genotype and phenotype data is extremely computationally demanding. This high cost may force researchers to conduct overly simplistic simulations that fail to accurately measure method performance. Alternatively, summary statistics can be simulated directly from their theoretical distribution. Although this is a common need among statistical genetics researchers, no software packages exist for comprehensive GWAS summary statistic simulation. We present GWASBrewer, an open source R package for direct simulation of GWAS summary statistics. We show t

SUBMITTER: Morrison J 

PROVIDER: S-EPMC11656154 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature