Extracellular vesicles epitopes as potential biomarker candidates in patients with traumatic spinal cord injury.

ABSTRACT:

Background

Extracellular vesicles (EVs), a heterogeneous group of cell-derived, membrane-enclosed vesicles bearing cell-specific epitopes, have been demonstrated to play a crucial role in neuronal-glial communication and the orchestration of neuroinflammatory processes. However, the existing evidence regarding their function as biomarkers and their role in the pathobiology of traumatic spinal cord injuries (tSCI), particularly in humans, is scarce.

Objective

The primary goal of this study was to investigate whether a distinct pattern of EV surface epitopes detected in the plasma of individuals suffering from spinal cord injury is indicative of tSCI.

Methods

The study includes patients with isolated tSCI (n=8), polytrauma patients without tSCI (PT; ISS ≥16, n=8), and h

SUBMITTER: Horauf JA 

PROVIDER: S-EPMC11656158 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature