Divergent neurodegenerative patterns: Comparison of [¹⁸F] fluorodeoxyglucose-PET- and MRI-based Alzheimer's disease subtypes.

ABSTRACT: [¹⁸F] fluorodeoxyglucose (FDG)-PET and MRI are key imaging markers for neurodegeneration in Alzheimer's disease. It has been well established that parieto-temporal hypometabolism on FDG-PET is closely associated with medial temporal atrophy on MRI in Alzheimer's disease. Substantial biological heterogeneity, expressed as distinct subtypes of hypometabolism or atrophy patterns, has been previously described in Alzheimer's disease using data-driven and hypothesis-driven methods. However, the link between these two imaging modalities has not yet been explored in the context of Alzheimer's disease subtypes. To investigate this link, the current study utilized FDG-PET and MRI scans from 180 amyloid-beta positive Alzheimer's disease dementia patients, 339 amyloid-beta positive mild co

SUBMITTER: Wheatley SH 

PROVIDER: S-EPMC11656166 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature