Antibacterial Coatings of Poly(ethylenimine)/Poly(l-lactide)-Grafted Hyaluronic Acid Multilayers Surface-Functionalized with Bacteriophages.

ABSTRACT: The infestation of tissue after implantation is a major problem as a bacterial biofilm can form on the surface of the implants, leading to implant-associated infections (IAIs). One approach to prevent such IAI is to apply antibacterial coatings consisting of polyelectrolyte multilayers (PEM) and bacteriophages (PHAGs). PEM were constructed by alternately adsorbing oppositely charged polyelectrolytes on a substrate according to the layer-by-layer concept. Poly(ethylenimine) (PEI) was used as the cationic polyelectrolyte, and a graft polymer of hyaluronic acid and poly(l-lactide) (DAC) was used as the anionic polyelectrolyte. Comparing PEM-5 (PEI/DAC/PEI/DAC/PEI) and PEM-6 (PEI/DAC/PEI/DAC/PEI/DAC), a higher amount of PHAG was bound to PEM-5 with cationic surface charge, which was detected b

SUBMITTER: Wirth L 

PROVIDER: S-EPMC11656210 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature