In Silico Modeling and Characterization of Epstein-Barr Virus Latent Membrane Protein 1 Protein.

ABSTRACT: Latent membrane protein 1 (LMP1) plays a crucial role in Epstein-Barr virus (EBV)'s ability to establish latency and is involved in developing and progressing EBV-associated cancers. Additionally, EBV-infected cells affect the immune responses, making it challenging for the immune system to eliminate them. Due to the aforementioned reasons, it is crucial to understand the structural features of LMP1, which are essential for the development of novel cancer therapies that target its signaling pathways. To date, there is yet to be a complete LMP1 protein structure; therefore, in our work, we modeled the full-length LMP1 containing the short cytoplasmic N-terminus, six transmembrane domains (TMDs), and a long-simulated C-terminus. Our model showed good stability and protein compactness evaluat

SUBMITTER: Salam DDA 

PROVIDER: S-EPMC11656244 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature