Simple Preparation and Bone Regeneration Effects of Poly(vinyl alcohol)-Resveratrol Self-Cross-Linked Hydrogels.

ABSTRACT: Hydrogels have broad application prospects in bone repair. Pure poly(vinyl alcohol) (PVA) hydrogels have limited applications because of their low hardness and poor mechanical properties. This study found that resveratrol (Res) and PVA self-assembled and cross-linked through the formation of strong hydrogen bonds after freeze-thawing, forming an easily available PVA-Res supramolecular hydrogel through a green process. PVA-Res hydrogels with different Res wt %:10 wt % PVA ratios were prepared through freeze-thawing and designated as 0.4, 1.2, and 2.0 wt % PVA-Res hydrogels. Rheological studies demonstrated that the viscoelastic modulus of the PVA-Res hydrogels was significantly improved compared to pure PVA hydrogels. The viscoelastic modulus G' of 1.2% PVA-Res hydrogel was 2299 Pa,

SUBMITTER: Li P 

PROVIDER: S-EPMC11656249 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature