Clinical advantages of incorporating predicted weekly anatomy in IMPT optimization with reduced setup error.

ABSTRACT:

Background

In head and neck (H&N) cancer treatment, a conventional setup error (SE) of 3mm is often used in robust optimization (cRO3mm). However, cRO3mm may lead to excessive radiation doses to organs at risk (OARs) and does not purposefully compensate for interfractional anatomy variations.

Purpose

This study introduces a method using predicted images from an anatomical model and a reduced 1mm SE uncertainty for robust optimization (aRO1mm), aiming to decrease the dose to OARs without affecting the coverage of the clinical target volume (CTV).

Methods

This retrospective study involved 10 nasopharynx radiotherapy patients. Validation CT scans (vCT) from treatment weeks 1 to 6 were analyzed. A predictive anatomical model, designed to capture the average anatomical cha

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11656292 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature