Phase-contrast visualization of human tissues using superimposed wavefront imaging of diffraction-enhanced x-rays.

ABSTRACT:

Background

Phase-contrast computed tomography (CT) using high-brilliance, synchrotron-generated x-rays enable three-dimensional (3D) visualization of microanatomical structures within biological specimens, offering exceptionally high-contrast images of soft tissues. Traditional methods for phase-contrast CT; however, necessitate a gap between the subject and the x-ray camera, compromising spatial resolution due to penumbral blurring. Our newly developed technique, Superimposed Wavefront Imaging of Diffraction-enhanced x-rays (SWIDeX), leverages a Laue-case Si angle analyzer affixed to a scintillator to convert x-rays to visible light, capturing second-order differential phase contrast images and effectively eliminating the distance to the x-ray camera. This innovation achieves supe

SUBMITTER: Sunaguchi N 

PROVIDER: S-EPMC11656296 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature